Solutions

We have a solution for everything – and the corresponding experience. In our current seven areas of expertise, we are at your disposal with our comprehensive know-how.

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Software solutions

Software solutions

With our Werum PAS-X MES - on premise or cloud-based - and our software solutions for analysis, track & trace, networked factories, and intelligent packaging, we are the world's leading supplier and partner to the pharmaceutical and biotech industries.

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Handling systems

Handling systems

We are specialists for complete handling systems for pharmaceutical and medical products. Our solutions are decisive in the field of contactless and safe transport of e.g. glass syringes.

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Inspection machines

Inspection

As the world's leading inspection expert, we develop solutions for the pharmaceutical and biotech industries. Our range of products extends from high-performance machines and semi-automatic machines to laboratory units and inspection applications for in-process control.

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Machine finder

Packaging machines

Packaging machines

We are a leading supplier of packaging machines for liquid and solid pharmaceutical and medical products. With our blister, sachet and stick packaging machines we offer solutions for primary packaging. Our side and topload cartoners set standards worldwide for secondary packaging.

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K.Pak Topload Case Packer

Introducing our latest solution from Körber; the K.Pak Topload Case Packer! Created specifically for the pharmaceutical industry, the K.Pak solution provides operator-friendly machines to complete any production line. Our solution focuses on innovative technology, high-quality design and expert handling and packaging of your product. It’s time to start connecting the dots with Körber!

Packaging solutions

Packaging solutions

As long-standing specialists, we develop packaging solutions for innovative and high-quality secondary pharmaceutical packaging made of cardboard. We offer you solutions for counterfeit protection, standard folding boxes and much more.

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Consulting

Consulting

Our experts will advise you during the analysis of your requirements, show you optimisation potential and support you during the implementation of projects in all areas of the pharmaceutical, biotech and medical device industry.

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Prof. Dr. Christoph Herwig
Senior Scientific Advisor, Körber Business Area Pharma

Blog

Integrated Bioprocess Data Analytics

Bioprocess data creates value for biotech companies. No doubt. Accelerated process development. Investigation & troubleshooting. Operations excellence. Assess optimization potential. Just to name a few use cases. Industry 4.0. Digitalization of the processing environment. New sensor technologies and data integrity requirements disrupt how process data is managed and analyzed. As a result, requirements for data management and bioprocess data analytics change dramatically. Today, data sources are very complex and multidimensional. Spectra from spectroscopic sensors, such as NIR and Raman, images from flow cytometry and in-line microscopes, mass spectrometry chromatograms, time-series sensor data, quality data, software sensors. Upstream. Downstream. Just to name a few. New solutions capable of managing and analyzing all process-relevant data types are necessary.

Process data is now multidimensional and of multiple origins

Industry 4.0 and process digitalization brought birth to new process analytical technologies. Processes are better monitored than ever before. The technological possibilities to mine chemical-, physical- and biological data from manufacturing are cheaper and more accurate than ever before. A great quantity of big process data is collected on a routine basis. But data size is not the issue. Data sources are now multidimensional and need to be aligned holistically, contextualized for doing value-added bioprocess data analytics. This is an issue. For integrated bioprocess data analytics, we need to wrangle all relevant data sources. The images below give a brief overview of data types you encounter in bioprocessing.

The new data sources and novel sensor technologies require new ways to analyze data. So far, nobody can analyze spectral data, sensor data, and quality data simultaneously. Data is in multiple database systems. Data needs to be combined and restructured for the analysis. This is data wrangling.

The most common way to wrangle data today is in spreadsheets. Data is imported from various historians, time-series databases, LIMS, or MES systems. Then an engineer or process data analyst sits for weeks wrangling the data. As a result, he has a nice spreadsheet. A spreadsheet nobody else can reuse. No data integrity is given. No traceability of the process is provided; significant data sets from 2D and 3D data are still left out. Today engineers and process analysts spend most of their time wrangling with spreadsheets. For more complex data sources, it is even impossible to use spreadsheets.

“Era of Industry 4.0. Analytics of process data using spreadsheets is not feasible anymore.”

But how to deal with the new wave of complex data sources? How to wrangle spectral, time-series, picture, and document information? How to mine information and bring this data in a combined form for dashboarding, analytics, and reporting?

Analyze spectral, image, and time-series process data in one step

The solution is integrated bioprocess data analytics. Integrated bioprocess data analytics takes data from time-series databases, spectral databases, MES systems, and LIMS systems. Data is wrangled to be available for bioprocess data analytics. Unique to integrated bioprocess data analytics is the capability to mine features (so-called Process Performance Indicators = PPI) from the data sources. For example, time-series data is condensed to single values of PPIs with high meaning, such as mean, median, average, and standard deviations.

A new way for bioprocess data analytics – integrated data analytics

The same we do for document/ image information. Algorithms mine PPIs from images. We extract features such as roughness, compactness, saturation. The same happens for spectral or chromatography data, in which not only peak heights bus also 1st and 2nd derivatives and tailing features. Algorithms mine PPIs from spectral data. This happens in a feature mining engine dedicated to mining PPIs from complex datasets. As a result, you have process performance indicators from your datasets.

Based on process performance indicators, bioprocess data analytics is easy. You can dashboard your PPIs to perform technology transfers, scale-up, process characterization , and continued process verification. You can provide visual analytics for engineers and scientists or let data scientists access this information to run predictive and machine learning algorithms.

  • Data wrangling
    Complex data is wrangled in a system capable of dealing with time series, image, and spectral data. Data is contextualized and ready for value-added data analytics.
  • Process Performance Indicators (PPIs)
    A feature mining engine mines process performance indicators from sensor data, images, and pictures
  • Data Analytics
    Scientists/ engineers and managers analyze process performance indicators for the entire process chain

PAS-X Savvy software for integrated bioprocess data analytics

PAS-X Savvy software is the first software platform dedicated to integrated process analytics based on holistic PPI analysis. Wrangle and analyze all process-relevant data sources. The unique feature mining engine enables the process of complex data to easily accessible PPIs. Dashboard and multivariate analytics functionality. Analyze all your data. Fast. Intuitive. In Real-time.

Request a personal demo

We’d love the opportunity to demo PAS-X Savvy to your team, answer your questions and explore whether PAS-X Savvy® would be a good fit. Request a demo now, and one of our experts will get in touch with you shortly.

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