Werum PAS-X Chromatography Control: improved process performance through AI and predictive analytics

Would you like to know in advance how much product yield you can expect from your commercial process chromatography? With Werum PAS-X Chromatography Control you can look into the future and make reliable pooling decisions based on yield and product purity.

The downstream processing of biotechnologically produced pharmaceuticals or active ingredients often counts for the most challenging part of any bioprocess. Chromatography is considered one of the most established separation methods, both for the initial isolation of the product and for the subsequent, often multi-tiered fine purification.

The target product should be present at the end of chromatographic purification in maximum yield and purity as specified. Yield loss constitutes a significant cost factor, especially on a commercial scale. Process- or product-related contaminations are not only a potential hazard for patients, but also result in considerable additional costs for extensive OOX investigations or, in the worst case, the disposal of an entire batch if the defined specification is exceeded.

In order to make the cost- and time-intensive purification process more economical and streamlined, the continuous optimization of individual isolation and purification sequences is a necessary measure. The yield/purity ratio is the key aspect in the field of chromatography and the basis for optimization approaches. Werum PAS-X Chromatography Control is designed to help you get the most out of your industrial process chromatography.

With our combination of proven artificial intelligence, high-performance real-time analysis and smart recommendations for action, you can make yield- and product purity-related pooling decisions – at an early stage, objectively and reproducibly.

The artificial intelligence of PAS-X Chromatography Control is based on Deep Learning, a specific form of machine learning with an artificial neural network architecture. 
Our data science and AI experts first train the neural network using historical chromatography data as a reference. The prediction model adapted to the data is then validated, verified for its predictive quality and further quality criteria, and then integrated into the purification process. In combination with a defined set of rules and current chromatography data, PAS-X Chromatography Control can now anticipate the most suitable time for fractionation of your product based on the expected product yield and purity – with a prediction quality of more than 95 percent!

This makes PAS-X Chromatography Control a powerful tool for supervising your chromatographic purification process. You will be able to react to process irregularities at an early stage or even, ultimately, to integrate model-based predictive control into your purification in combination with your process control system. 

Contact us for a first, no-obligation consultation for your production process!

PAS-X Chromatography Control is a field-proven product that is under continuous development with a leading multinational pharmaceutical and life science company based in Germany. The individual isolation and purification steps of the large-scale plant for the biotech production of active ingredients are very complex and require a thorough understanding of all parameters involved. Until now, experienced employees determined the start and end times for chromatographic fractionation and separation of the active ingredient based on IPC data. 

With Werum PAS-X Chromatography Control, the company has found an innovative way to support the professionals involved in their decisions, to eliminate potential sources of variability in this important process phase, and to significantly increase product yields while maintaining purity.